Don’t let Arthritis get in the way of your day. TYLENOL ® 8 HR ARTHRITIS Pain provides two layers of pain relief that work fast and last all day* How to use Tylenol Arthritis Tablet, Extended Release. Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information. Acetaminophen Won't Help Arthritis Pain, Study Finds. Prescription diclofenac a more effective choice for short-term pain relief, researchers say Whether you need relief from arthritis pain or a garden-variety headache, sinus discomfort or menstrual cramps, this guide to the similarities and differences between the various Tylenol products plus important information about taking any form of acetaminophen safely should help you hone in on the one that will work best for you. Even though Tylenol has been around for quite a while, it is not entirely clear how it works. However, the product has been shown to work differently from any other over-the-counter (OTC) medicines. You may need to have your blood work checked more closely while you are taking it with Tylenol Arthritis Pain (acetaminophen controlled-release tablets). This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Tylenol Arthritis Pain (acetaminophen controlled-release tablets). Tylenol may relieve minor aches and pains and reduce fever. It has little anti-inflammatory effect, though, which means it won’t do much for pain from inflammatory arthritis. I used other brands before using Tylenol Arthritis. I had to take several pills a day to stop the pain. After starting to use Tylenol Arthritis, I only have to use one or two a day. Really stops the pain quickly. Arthritis expert Dr. Bashir Zikria, an assistant professor of orthopaedic surgery at the Johns Hopkins University School of Medicine, said there's been limited research comparing acetaminophen. Tylenol (acetaminophen) is a commonly used over-the-counter medication that helps in reducing pain and fever.It is used in people of all age groups with many different medical conditions.Such conditions are known to be the muscle ache, backache, headache, cold, toothache, arthritis and many more.Other names of this medication include Excedrin.